Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]
Foreign currency translation
Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax
Unrealized gain (loss) on marketable securities
Accumulated Other Comprehensive Income (Loss), Debt Securities, Available-for-sale, Adjustment, after Tax
Accumulated other comprehensive income
Accumulated Other Comprehensive Income (Loss), Net of Tax
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies [Table]
Commitments and Contingencies [Table]
Commitments and contingencies.
Range [Axis]
Range [Axis]
Range [Domain]
Range [Domain]
Maximum
Maximum [Member]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Regulatory Approval Milestone
Regulatory Approval Milestone [Member]
Regulatory Approval Milestone [Member]
Future Regulatory Approval And Sales Milestones
Future Regulatory Approval And Sales Milestones [Member]
Future Regulatory Approval And Sales Milestones [Member]
Development And Milestone Payment, Conclusion Of Phase I Study
Development And Milestone Payment, Conclusion Of Phase I Study [Member]
Development And Milestone Payment, Conclusion Of Phase I Study [Member]
Product and Service [Axis]
Product and Service [Axis]
Product and Service [Domain]
Product and Service [Domain]
CFTR Activators and Inhibitors
CFTR activators and inhibitors [Member]
CFTR activators and inhibitors [Member]
Commitments and Contingencies [Line Items]
Commitments and Contingencies [Line Items]
Commitments and contingencies.
Future percentage of royalty payments based net sales
Future Percentage Of Royalty Payments Based On Net Sales
Future Percentage Of Royalty Payments Based On Net Sales.
CFTR activators and inhibitors
CFTR activators and inhibitors [Abstract]
CFTR activators and inhibitors [Abstract]
Possible future milestone payments
Development And Milestone Payments Potentially Due To Third Party
Total amount potentially due to third party under license agreement based on achievement of pre-new drug application approval milestones.
Milestone payment under license agreement
Upfront License Fee And Milestone Payments Made
Upfront and milestone payments made to third parties for in-licensed products that have not yet received marketing approval and for which no alternative future use has been identified. Amounts are expensed as research and development costs when incurred.
Accounting Policies [Abstract]
Net Sales by Product
Revenue from External Customers by Products and Services [Table Text Block]
Schedule of Cash Flow, Supplemental Disclosures
Schedule of Cash Flow, Supplemental Disclosures [Table Text Block]
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Income Statement Location [Axis]
Income Statement Location [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Research and development
Research and Development Expense [Member]
Selling, general and administrative
Selling, General and Administrative Expenses [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Stock-based compensation expense
Allocated Share-based Compensation Expense
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of Finite-Lived Intangible Assets [Table]
Schedule of Finite-Lived Intangible Assets [Table]
HETLIOZ®
Hetlioz [Member]
Hetlioz [Member]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets [Line Items]
Acquisition of intangible assets
Payments to Acquire Intangible Assets
Cumulative worldwide sales milestone
Cumulative Net Sales To Achieve Milestone
Net cumulative worldwide sales to achieve milestone and trigger payment of milestone obligation.
Intangible assets capitalized
Finite-Lived Intangible Assets, Period Increase (Decrease)
Income Statement [Abstract]
Revenues:
Revenues [Abstract]
Net product sales
Revenue from Contract with Customer, Excluding Assessed Tax
Total revenues
Revenues
Operating expenses:
Costs and Expenses [Abstract]
Cost of goods sold excluding amortization
Cost of Goods Sold, Excluding Depreciation, Depletion, and Amortization
Research and development
Research and Development Expense
Selling, general and administrative
Selling, General and Administrative Expense
Intangible asset amortization
Amortization of Intangible Assets
Total operating expenses
Costs and Expenses
Income from operations
Operating Income (Loss)
Other income
Other Income
Income before income taxes
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest
Provision (benefit) for income taxes
Income Tax Expense (Benefit)
Net income
Net Income (Loss) Attributable to Parent
Net income per share:
Earnings Per Share [Abstract]
Basic (in dollars per share)
Earnings Per Share, Basic
Diluted (in dollars per share)
Earnings Per Share, Diluted
Weighted average shares outstanding:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
New Accounting Pronouncements or Change in Accounting Principle [Table]
New Accounting Pronouncements or Change in Accounting Principle [Table]
Adjustments for New Accounting Pronouncements [Axis]
Adjustments for New Accounting Pronouncements [Axis]
Type of Adoption [Domain]
Type of Adoption [Domain]
Accounting Standards Update 2016-02
Accounting Standards Update 2016-02 [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Operating lease liability
Operating Lease, Liability
Operating lease current liabilities
Operating Lease, Liability, Current
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Leases [Abstract]
Total
Operating Leases, Future Minimum Payments Due
2019
Operating Leases, Future Minimum Payments Due, Next Twelve Months
2020
Operating Leases, Future Minimum Payments, Due in Two Years
2021
Operating Leases, Future Minimum Payments, Due in Three Years
2022
Operating Leases, Future Minimum Payments, Due in Four Years
2023
Operating Leases, Future Minimum Payments, Due in Five Years
Thereafter
Operating Leases, Future Minimum Payments, Due Thereafter
Type of Arrangement and Non-arrangement Transactions [Axis]
Type of Arrangement and Non-arrangement Transactions [Axis]
Arrangements and Non-arrangement Transactions [Domain]
Arrangements and Non-arrangement Transactions [Domain]
VQW-765
VQW-765 [Member]
VQW-765 [Member]
Summary of Accumulated Balances Related to Each Component of Other Comprehensive Income (Loss)
Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]
Schedule Of Lease Assets And Liabilities
Schedule Of Lease Assets And Liabilities [Table Text Block]
Schedule Of Lease Assets And Liabilities [Table Text Block]
Lessee, Operating Lease, Liability, Maturity
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Schedule of Future Minimum Rental Payments for Operating Leases
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Schedule of Cash and Cash Equivalents [Table]
Schedule of Cash and Cash Equivalents [Table]
Balance Sheet Location [Axis]
Balance Sheet Location [Axis]
Balance Sheet Location [Domain]
Balance Sheet Location [Domain]
Prepaid expenses and other current assets
Prepaid Expenses and Other Current Assets [Member]
Non-current inventory and other
Noncurrent Inventory and Other [Member]
Noncurrent Inventory and Other [Member]
Cash and Cash Equivalents [Line Items]
Cash and Cash Equivalents [Line Items]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Restricted cash included in:
Restricted Cash and Cash Equivalents [Abstract]
Restricted cash
Restricted Cash and Cash Equivalents
Total cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Weighted average expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate
Weighted average expected term (years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Weighted average risk-free rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
2019
Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year
2020
Lessee, Operating Lease, Liability, Payments, Due Year Two
2021
Lessee, Operating Lease, Liability, Payments, Due Year Three
2022
Lessee, Operating Lease, Liability, Payments, Due Year Four
2023
Lessee, Operating Lease, Liability, Payments, Due Year Five
Thereafter
Lessee, Operating Lease, Liability, Payments, Due after Year Five
Total minimum lease payments
Lessee, Operating Lease, Liability, Payments, Due
Less: amount of lease payments representing interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Total lease liabilities
Less: current obligations under leases
Operating lease non-current liabilities
Operating Lease, Liability, Noncurrent
Statement of Comprehensive Income [Abstract]
Net income
Other comprehensive income (loss):
Other Comprehensive Income (Loss), before Tax [Abstract]
Net foreign currency translation loss
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, before Tax
Change in net unrealized gain (loss) on marketable securities
Other Comprehensive Income (Loss), Securities, Available-for-sale, Adjustment, before Tax
Tax provision on other comprehensive income (loss)
Other Comprehensive Income (Loss), Tax
Other comprehensive income (loss), net of tax
Other Comprehensive Income (Loss), Net of Tax
Comprehensive income
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Inventory Disclosure [Abstract]
Current:
Inventory, Net [Abstract]
Work-in-process
Inventory, Work in Process, Net of Reserves
Finished goods
Inventory, Finished Goods, Net of Reserves
Total inventory, current
Inventory, Net
Non-Current:
Inventory, Noncurrent [Abstract]
Raw materials
Inventory, Raw Materials, Net of Reserves, Non Current
Raw materials inventories not expected to be converted to cash, sold or exchanged within the normal operating cycle.
Work-in-process
Inventory, Work in Process, Net of Reserves, Non Current
Work in process inventories not expected to be converted to cash, sold or exchanged within the normal operating cycle.
Finished goods
Inventory, Finished Goods, Net of Reserves, Non Current
Finished goods inventories not expected to be converted to cash, sold or exchanged within the normal operating cycle.
Total inventory, non-current
Inventory, Noncurrent
Total inventory
inventory
inventory
HETLIOZ
Hetlioz [Abstract]
Hetlioz [Abstract]
Royalty payment period
Royalty Period
Royalty Period
Royalty payable percentage on net sales
Royalty Payable On Net Sales Percentage
Royalty payable percentage under a contractual arrangement for use of technology or intellectual property.
Percentage of future sublicense fees payable to third-party
Percentage Of Future Sublicense Fees Payable
Percentage of sublicense fees payable to third party under a contractual arrangement for use of technology or intellectual property.
Summary of Option Activity Plan
Share-based Compensation, Stock Options, Activity [Table Text Block]
Summary of RSU Activity for 2006 Plan and 2016 Plan
Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block]
Stock-Based Compensation Expense
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
Black-Scholes-Merton Option Pricing Model for Employee and Director Stock Options Granted
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Plan Name [Axis]
Plan Name [Axis]
Plan Name [Domain]
Plan Name [Domain]
2006 Plan and 2016 Plan
Two Thousand Six Plan and Two Thousand Sixteen Plan [Member]
Two Thousand Six Plan and Two Thousand Sixteen Plan [Member]
2016 Plan
Two Thousand Sixteen Plan [Member]
Two Thousand Sixteen Plan [Member]
Award Type [Axis]
Award Type [Axis]
Equity Award [Domain]
Equity Award [Domain]
Outstanding options and RSUs granted (RSUs)
Stock Options and Restricted Stock Units (RSUs) [Member]
Stock Options and Restricted Stock Units (RSUs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares subject to outstanding options and RSUs (in shares)
Share Based Compensation Arrangement by Share Based Payment Award Options and Restricted Stock Units (RSUs) Outstanding Number
Number of options outstanding, including vested and non-vested options, as of the balance sheet, plus the number of non-vested restricted stock units outstanding as of the balance sheet date.
Number of shares of common stock reserved for issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Number of shares of common stock available for future grant (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Geographical [Axis]
Geographical [Axis]
Geographical [Domain]
Geographical [Domain]
UNITED STATES
UNITED STATES
Europe
Europe [Member]
Tradipitant
Tradipitant [Member]
Tradipitant [Member]
Development and Milestone Payments of Phase III Study Potentially Due to Third Party
Development and Milestone Payments of Phase Three Study Potentially Due to Third Party [Member]
Development and Milestone Payments of Phase Three Study Potentially Due to Third Party [Member]
Sales Milestone
Sales Milestone [Member]
Sales Milestone [Member]
Possible future milestone payment
Milestone obligation under license agreement
Milestone Obligation Under License Agreement Current
Carrying value as of the balance sheet date for accrued current liability relating to obligations to make a probable future milestone payments that would become due and payable when the related milestones are achieved.
Fair Value Disclosures [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Payables and Accruals [Abstract]
Summary of Accounts Payable and Accrued Liabilities
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Fanapt®
Fanapt [Member]
Fanapt.
Statement, Scenario Secondary [Axis]
Statement, Scenario Secondary [Axis]
Statement, Scenario Secondary [Axis]
Statement, Scenario Secondary [Domain]
Statement, Scenario Secondary [Domain]
Statement, Scenario Secondary [Domain]
November 16,2016 through December 31,2019
Scenario 4 [Member]
Scenario 4 [Member]
Fanapt
Fanapt [Abstract]
Fanapt [Abstract]
Leases
Lessee, Operating Leases [Text Block]
Summary of Non-cancelable Long-term Contractual Cash Obligations
Contractual Obligation, Fiscal Year Maturity Schedule [Table Text Block]
Inventory
Inventory Disclosure [Text Block]
Fully amortized intangible assets
Finite-Lived Intangible Assets, Gross
Net Carrying Amount
Finite-Lived Intangible Assets, Net
2019
Finite-Lived Intangible Assets, Amortization Expense, Remainder of Fiscal Year
2020
Finite-Lived Intangible Assets, Amortization Expense, Year Two
2021
Finite-Lived Intangible Assets, Amortization Expense, Year Three
2022
Finite-Lived Intangible Assets, Amortization Expense, Year Four
2023
Finite-Lived Intangible Assets, Amortization Expense, Year Five
Thereafter
Finite-Lived Intangible Assets, Amortization Expense, after Year Five
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Leases
Lessee, Leases [Policy Text Block]
Major Customers
Major Customers, Policy [Policy Text Block]
Cash, Cash Equivalents and Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Marketable securities
Marketable Securities, Policy [Policy Text Block]
Inventory
Inventory, Policy [Policy Text Block]
Earnings per Share
Earnings Per Share, Policy [Policy Text Block]
Sublease
Sublease [Member]
Sublease [Member]
Lease Arrangement, Type [Axis]
Lease Arrangement, Type [Axis]
Lease Arrangement, Type [Domain]
Lease Arrangement, Type [Domain]
Washington DC Lease
Washington DC Lease [Member]
Washington DC Lease [Member]
London Lease
London Lease [Member]
London Lease [Member]
Leased square footage
Area of Real Estate Property
Renewal term of lease agreement
Lessee, Operating Lease, Renewal Term
Operating lease cost
Operating Lease, Cost
Short-term lease cost
Short-term Lease, Cost
Non-lease component expense
Operating Lease, Non-Lease Component Expense
Operating Lease, Non-Lease Component Expense
Rent expense
Operating Leases, Rent Expense
Operating lease, payments
Operating Lease, Payments
Revenue from External Customers by Products and Services [Table]
Revenue from External Customers by Products and Services [Table]
HETLIOZ® product sales, net
Fanapt® product sales, net
Revenue from External Customer [Line Items]
Revenue from External Customer [Line Items]
Accumulated Other Comprehensive Income (Loss)
Comprehensive Income (Loss) Note [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Statement of Cash Flows [Abstract]
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Adjustments to reconcile net income to net cash provided by operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Depreciation of property and equipment
Depreciation
Stock-based compensation
Share-based Compensation
Amortization of discounts on marketable securities
Investment Income, Net, Amortization of Discount and Premium
Deferred income taxes
Deferred Income Tax Expense (Benefit)
Other non-cash adjustments, net
Other Noncash Income (Expense)
Changes in operating assets and liabilities:
Increase (Decrease) in Other Operating Assets and Liabilities, Net [Abstract]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Inventory
Increase (Decrease) in Inventories
Accounts payable and other liabilities
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Product revenue allowances
Increase (Decrease) Product Revenue Allowances
The increase (decrease) during the reporting period in the amount of obligations and expenses incurred but not paid for product revenue allowances.
Net cash provided by operating activities
Net Cash Provided by (Used in) Operating Activities
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Acquisition of intangible asset
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-sale
Maturities of marketable securities
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Net proceeds from offering of common stock
Proceeds from Issuance of Common Stock
Proceeds from the exercise of stock options
Proceeds from Stock Options Exercised
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Effect of exchange rate changes on cash, cash equivalents and restricted cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Net change in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents [Abstract]
Beginning of period
End of period
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Denominator:
Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]
Weighted average shares outstanding, basic (in shares)
Effect of dilutive securities (in shares)
Weighted Average Number Diluted Shares Outstanding Adjustment
Weighted average shares outstanding, diluted (in shares)
Net income per share, basic and diluted:
Earnings Per Share, Basic and Diluted [Abstract]
Antidilutive securities excluded from calculations of diluted net income per share (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Operating lease assets
Operating lease non-current liabilities
Weighted average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of operating segments
Number of Operating Segments
Statement of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets:
Assets, Current [Abstract]
Cash and cash equivalents
Marketable securities
Debt Securities, Available-for-sale, Current
Accounts receivable, net
Accounts Receivable, Net, Current
Inventory
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total current assets
Assets, Current
Marketable securities, non-current
Debt Securities, Available-for-sale, Noncurrent
Property and equipment, net
Property, Plant and Equipment, Net
Intangible assets, net
Deferred tax assets
Deferred Tax Assets, Net, Noncurrent
Non-current inventory and other
Inventory and Other Non Current
Carrying amount as of the balance sheet date of inventories not expected to be converted to cash, sold or exchanged within the normal operating cycle and other non current assets.
Total assets
Assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Liabilities and Equity [Abstract]
Current liabilities:
Liabilities, Current [Abstract]
Accounts payable and accrued liabilities
Accounts Payable and Accrued Liabilities, Current
Product revenue allowances
Product Revenue Allowances, Current
Product Revenue Allowances, Current
Milestone obligations under license agreements
Total current liabilities
Liabilities, Current
Operating lease non-current liabilities
Other non-current liabilities
Other Liabilities, Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Notes 9 and 15)
Commitments and Contingencies
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Preferred stock, $0.001 par value; 20,000,000 shares authorized, and no shares issued or outstanding at September 30, 2019 and December 31, 2018
Preferred Stock, Value, Issued
Common stock, $0.001 par value; 150,000,000 shares authorized; 53,333,211 and 52,477,593 shares issued and outstanding at September 30, 2019 and December 31, 2018, respectively
Common Stock, Value, Issued
Additional paid-in capital
Additional Paid in Capital, Common Stock
Accumulated other comprehensive income
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Total stockholders’ equity
Stockholders' Equity Attributable to Parent
Total liabilities and stockholders’ equity
Liabilities and Equity
Accounts Payable and Accrued Liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Number of Shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Beginning balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Expired (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Ending balance (in shares)
Exercisable (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Vested and expected to vest at end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Weighted Average Exercise Price at Grant Date
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Beginning balance (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Forfeited (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Expired (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Ending balance (in dollars per share)
Exercisable (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Vested and expected to vest at end of period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted Average Remaining Term (Years)
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Remaining Contractual Term [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Remaining Contractual Term [Abstract]
Weighted Average Remaining Term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Vested and expected to vest at end of period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Aggregate Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract]
Beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Ending balance
Exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Vested and expected to vest at end of period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Earnings per Share
Earnings Per Share [Text Block]
Service option awards
Service Option Awards [Member]
Service Option Awards [Member]
Share based compensation option awards contractual term
Share Based Compensation Option Awards Contractual Term
Contractual term of stock option awards.
Portion of initial stock options granted to employees that vests on employee's first anniversary
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Share Subject To Option Awards
Percentage of new hire stock option award that vests after one year of service.
Portion of initial stock options granted to employees that vests ratably over three years after completion of first year of service
Share Based Compensation Arrangement By Share Based Payment Award Remaining Percentage Of Share Subject To Option Awards
Percentage of new hire stock option award that vests monthly after one year of service.
Option awards vesting period, after completion of one year of service
Option Awards Vesting Period After Completion Of One Year Of Service
Monthly vesting period for new hire option awards after one year of service.
Vesting period for subsequent stock options granted to directors
Share Based Compensation Arrangement by Share Based Payment Annual Award Vesting Period Directors
Period which a director's right to exercise an annual option award is no longer contingent on satisfaction of either a service, market or a performance condition.
Unrecognized compensation expenses
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Unrecognized compensation expenses, weighted average period
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Options granted, weighted average fair value per share (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Proceeds from exercise of employee stock options
Basic and Diluted Net Loss Per Share of Common Stock
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name [Domain]
Research Tax Credit
Other Components Of Net Income Tax Expense (Benefit) [Member]
Other Components Of Net Income Tax Expense (Benefit) [Member]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Income tax expense (benefit)
Unrecognized tax benefits
Unrecognized Tax Benefits
Statement of Stockholders' Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components [Axis]
Equity Components [Axis]
Equity Component [Domain]
Equity Component [Domain]
Common Stock
Common Stock [Member]
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Other Comprehensive Income
AOCI Attributable to Parent [Member]
Accumulated Deficit
Retained Earnings [Member]
Statement [Line Items]
Statement [Line Items]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Beginning balance (in shares)
Common Stock, Shares, Outstanding
Beginning balance
Net proceeds from public offering of common stock (in shares)
Stock Issued During Period, Shares, New Issues
Net proceeds from public offering of common stock
Stock Issued During Period, Value, New Issues
Issuance of common stock form the exercise of stock options and settlement of restricted stock units (in shares)
Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures
Stock-based compensation expense
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Net income (loss)
Other comprehensive income (loss), net of tax
Ending balance (in shares)
Ending balance
Intangible Assets
Intangible Assets Disclosure [Text Block]
Equity [Abstract]
Public Offering of Common Stock
Public Offering Of Common Stock [Text Block]
Public Offering Of Common Stock [Text Block]
Investments, Debt and Equity Securities [Abstract]
Schedule of Available-for-sale Securities [Table]
Schedule of Available-for-sale Securities [Table]
Investment Type [Axis]
Investment Type [Axis]
Investments [Domain]
Investments [Domain]
Current Investments
Current Investment [Member]
Current investments.
Noncurrent Investments
Noncurrent Investments [Member]
Noncurrent Investments [Member]
Financial Instrument [Axis]
Financial Instrument [Axis]
Financial Instruments [Domain]
Financial Instruments [Domain]
U.S. Treasury and government agencies
US Treasury and Government [Member]
Corporate debt
Corporate Debt Securities [Member]
Asset-backed securities
Asset-backed Securities [Member]
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-sale [Line Items]
Amortized Cost
Debt Securities, Available-for-sale, Amortized Cost
Gross Unrealized Gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Fair Market Value
Debt Securities, Available-for-sale
Stock-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Agreements for clinical and marketing services, termination notice period
Agreements For Clinical And Marketing Services, Termination Notice Period
Agreements For Clinical And Marketing Services, Termination Notice Period
Summary of Intangible Assets
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Summary of Future Intangible Asset Amortization
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Legal Matters
Legal Matters and Contingencies [Text Block]
Consulting and other professional fees
Accrued Professional Fees, Current
Research and development expenses
Accrued Research And Development Expense
Carrying value as of the balance sheet date of obligations incurred and payable for research and development expenses (due within one year or within the normal operating cycle if longer).
Royalties payable
Accrued Royalties, Current
Compensation and employee benefits
Employee-related Liabilities, Current
Operating lease liabilities
Other
Other Accrued Liabilities, Current
Accounts payable and accrued liabilities
Business Organization and Presentation
Business Description and Basis of Presentation [Text Block]
Assets Measured at Fair Value on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Quoted Prices in Active Markets for Identical Assets (Level 1)
Fair Value, Inputs, Level 1 [Member]
Significant Other Observable Inputs (Level 2)
Fair Value, Inputs, Level 2 [Member]
Significant Unobservable Inputs (Level 3)
Fair Value, Inputs, Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value
Assets, Fair Value Disclosure
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Concentration Risk Type [Axis]
Concentration Risk Type [Axis]
Concentration Risk Type [Domain]
Concentration Risk Type [Domain]
Customer Concentration Risk
Customer Concentration Risk [Member]
Credit Concentration Risk
Credit Concentration Risk [Member]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Domain]
Concentration Risk Benchmark [Domain]
Sales Revenue, Net
Sales Revenue, Net [Member]
Accounts Receivable
Accounts Receivable [Member]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Number of major customers that each accounted for more than 10% of total revenues
Number Of Major Customers Accounted For Revenue
Number of major customers that each accounted for more than 10% of total revenues.
Concentration risk, percentage
Concentration Risk, Percentage
Number of major customers that each accounted for more than 10% of total accounts receivable
Number Of Major Customers Accounted For Trade Accounts Receivable
Number of major customers that each accounted for more than 10% of total accounts receivable.
Cover page.
Document Type
Document Type
Document Quarterly Report
Document Quarterly Report
Document Period End Date
Document Period End Date
Document Transition Report
Document Transition Report
Entity File Number
Entity File Number
Entity Registrant Name
Entity Registrant Name
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Two
Entity Address, City or Town
Entity Address, City or Town
Entity Address, State or Province
Entity Address, State or Province
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Title of 12(b) Security
Title of 12(b) Security
Trading Symbol
Trading Symbol
Security Exchange Name
Security Exchange Name
Entity Current Reporting Status
Entity Current Reporting Status
Entity Interactive Data Current
Entity Interactive Data Current
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Shell Company
Entity Shell Company
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Entity Central Index Key
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Amendment Flag
Amendment Flag
Inventory
Schedule Of Inventories [Table Text Block]
Schedule of inventories.
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Sale of Stock [Axis]
Sale of Stock [Axis]
Sale of Stock [Domain]
Sale of Stock [Domain]
Public Offering
Public Offering [Member]
Public Offering [Member]
Over-Allotment Option
Over-Allotment Option [Member]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Public offering of common stock (in shares)
Public offerings of common stock (in dollars per share)
Sale of Stock, Price Per Share
Net proceeds from public offering
Accumulated Other Comprehensive Income (Loss) [Table]
Accumulated Other Comprehensive Income (Loss) [Table]
Reclassification out of Accumulated Other Comprehensive Income [Axis]
Reclassification out of Accumulated Other Comprehensive Income [Axis]
Reclassification out of Accumulated Other Comprehensive Income [Domain]
Reclassification out of Accumulated Other Comprehensive Income [Domain]
Reclassification Out of Accumulated Other Comprehensive Income (Loss)
Reclassification out of Accumulated Other Comprehensive Income [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Reclassifications out of accumulated other comprehensive income (loss)
Reclassification from AOCI, Current Period, Net of Tax, Attributable to Parent
Summary of Available-for-Sale Marketable Securities
Debt Securities, Available-for-sale [Table Text Block]
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Gross Carrying Amount
Accumulated Amortization
Finite-Lived Intangible Assets, Accumulated Amortization
Purchase commitments
Purchase Obligation, Fiscal Year Maturity [Abstract]
Purchase commitments
Purchase Obligation
2019
Purchase Obligation, Future Minimum Payments, Remainder of Fiscal Year
2020
Purchase Obligation, Due in Second Year
2021
Purchase Obligation, Due in Third Year
2022
Purchase Obligation, Due in Fourth Year
2023
Purchase Obligation, Due in Fifth Year
Thereafter
Purchase Obligation, Due after Fifth Year
Restricted Stock Units (RSU)
Restricted Stock Units (RSUs) [Member]
Vesting period of RSU awards in equal installments
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vesting Period One
Period which an employee's right to exercise an equity instrument other than options is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Unrecognized compensation expenses related to unvested RSUs
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options
Grant date fair value of common stock granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Grant date fair value of common stock vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Common stock, shares outstanding (in shares)
Schedule of Share based Compensation Arrangements by Share based Payment Award, Equity Instruments, Other Than Options, Restricted Stock Units [Table]
Schedule of Share based Compensation Arrangements by Share based Payment Award, Equity Instruments, Other Than Options, Restricted Stock Units [Table]
Schedule of Share based Compensation Arrangements by Share based Payment Award, Equity Instruments, Other Than Options, Restricted Stock Units [Table]
Schedule of Share based Compensation Arrangements by Share based Payment Award, Equity Instruments, Other Than Options, Restricted Stock Units [Line Items]
Schedule of Share based Compensation Arrangements by Share based Payment Award, Equity Instruments, Other Than Options, Restricted Stock Units [Line Items]
Schedule of Share based Compensation Arrangements by Share based Payment Award, Equity Instruments, Other Than Options, Restricted Stock Units [Line Items]
Number of Shares Unvested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Beginning balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Vested (in shares)
Ending balance (in shares)
Weighted Average Price/Share Unvested
Share based Compensation Arrangement by Share based Payment Award, Equity Instruments Other than Options, Weighted Average Grant Date Fair Value [Abstract]
Share based Compensation Arrangement by Share based Payment Award, Equity Instruments Other than Options, Weighted Average Grant Date Fair Value [Abstract]
Beginning balance (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Granted (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Forfeited (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Ending balance (in dollars per share)